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KMID : 1149220210290040285
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Korean Journal of Oriental Medical Prescription
2021 Volume.29 No. 4 p.285 ~ p.295
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Systematic Review of the Effects of Herbal Medicine Versus Synthetic Drugs on Helicobacter Pylori Infection
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Cho Eun-Ji
Jeong Seol
Gwak Seung-Yeon
Jerng Ui-Min
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Abstract
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Objective : This systematic review was conducted to investigate the effect of herbal medicine on Helicobacter pylori(H. pylori) infection compared to amoxicillin included synthetic drugs.
Methods : Relevant randomized controlled trials(RCTs) which were published prior to December 26, 2020, were collected using PubMED database. Risk of bias evaluation and data extraction were done independently by two reviewers, and the third reviewer reassessed mismatching parts.
Results : Two RCTs testing two different herbal medicines against synthetic drugs solitary treatment or synthetic drugs with placebo for herbal medicine were included. One study reported that there was no significant difference between the eradication rate of synthetic drugs and the herbal medicine. The other study did not report the eradication rate of the herbal medicine. One study reported histologic severity, the other reported dyspepsia score as efficacy indicators. There was no adverse event reported in all studies. However, the number of included RCTs was too small, the quality of reported data was not enough to verify efficacy of herbal medicine, and there were some methodological problems.
Conclusion : It was difficult to conclude that solitary treatment of herbal medicine was as effective as amoxicillin included synthetic drugs for H. pylori infection.
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KEYWORD
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Helicobacter pylori, Herbal medicine, Synthetic drugs, Amoxicillin, Systematic review
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